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High-fat or high-sugar meals whilst not contraindicated, these may worsen gastrointestinal side effects, particularly during the dose escalation phase

Dehydration occurs when the body loses more fluid than it takes in

The OASIS 4 double-blind, randomised controlled trial of oral semaglutide 25 mg daily was published in the same issue of the New England Journal of Medicine (Wharton et al, 2025b)

If the body cant use glucose, it gets stored as fat

It binds to toxins, heavy metals, and free radicals, making them easier for the body to eliminate

In theory, combining agents that both reduce adiposity and improve insulin sensitivity could produce additive or synergistic metabolic effects but this is entirely speculative and unproven in humans