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In that sense, the peptides design is quite deliberate: the tripeptide chain stabilizes copper while preventing excessive reactivity or toxicity

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By potentially downregulating TGF-1, AHK-Cu may alter these cellular processes, possibly affecting cell growth and the immune response at a cellular level

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The 2021 Akar paper in Journal of Obstetrics and Gynaecology documented anti-proliferative activity of small-molecule NNMT inhibitors in HeLa cell systems (PMID 33645410)