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Endocrine (2015) 49:517
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these drugs were made from the venom of the Gila lizard because the reptiles saliva contains the intestinally secreted peptide GLP1, and for some reason, it is more stable in lizards than humans
189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level
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