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doi: 10.3389/fonc.2022.916375 Received 09 April 2022 Accepted 06 July 2022 Published 02 August 2022 Volume 12 - 2022 Edited by Yahya Sohrabi, University Hospital Mnster, Germany Reviewed by Fay Probert, University of Oxford, United Kingdom
Unlike exogenous GH, sermorelin does not bypass the hypothalamic-pituitary axis, so side effects such as carpal tunnel syndrome, insulin resistance, edema, and joint pain are rare
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Ipamorelin works within the body's own feedback loops, meaning natural somatostatin suppression prevents GH from rising to excessive levels
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