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Patients should be aware of serious adverse effects requiring medical attention, including: severe abdominal pain with or without vomiting (pancreatitis)
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Specifically, it targets genes that control cell death, nerve growth, and brain plasticity
The pattern that emerges from this comprehensive comparison is that tirzepatide generally has a more favorable side effect profile for most categories, with the notable exceptions of injection site reactions and hair loss (which is weight-loss driven rather than drug-specific)
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A randomized clinical trial published in May 2026 in The Lancet investigated whether semaglutide, a GLP-1 peptide that acts as a GLP-1 receptor agonist and is approved for obesity treatment, was associated with changes in alcohol consumption among adults living with both obesity and alcohol use disorder
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