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Gastroenterology (2009) 137:164960
Current guidance states that treatment is indicated for adults with a BMI of 30 or above, or a BMI of 27 or above where there is at least one weight-related health condition, including in some higher-risk ethnic groups where lower BMI thresholds may still be clinically relevant
Orlistat (also available as branded Xenical) is a weight loss treatment that reduces how much fat is absorbed from food
Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)
Reviews of GLP-1 drugs describe gastrointestinal side effects as one of the main drawbacks
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