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leads to cell apoptosis (5) Whether H 2 reduced the cellular and mitochondrial oxidative stress, intracellular calcium influxes and inhibits the stress response MAPK, caspase cell signaling pathway through the activation of Nrf2/ARE signaling pathway (6) Consequently, increased the antioxidant enzymes and reduced the inflammatory cytokine that influences the macrophage cell proliferation (7) to protect the cell from apoptosis

J Intern Med (1997) 242(5):4139.10.1046/j.1365-2796.1997.00237.x 167 KellerJBeglingerCHolstJJAndresenVLayerP

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