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They work by stimulating insulin release, reducing glucagon secretion, and slowing digestion, which helps maintain stable blood sugar levels

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As the pharmacological action and impact on CV parameters interpreted from the CV outcomes trials seemingly differed between both classes of glucose-lowering agents, they should be used accordingly, that is, after taking into consideration a patients needs and drug tolerability

Track weekly weigh-ins, body measurements, and how clothes fit rather than obsessing over daily scale fluctuations

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These effects are initially mediated by natriuresis and plasma volume contraction, but sustained effects likely reflect additional mechanisms including reduced total body sodium, decrease in intracellular sodium and calcium, and vasodilation