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Development of GLP-1 receptor agonists The most important strategy to develop compounds with extended in vivo half-life of GLP-1 was by making DPP-4 resistant GLP-1 receptor agonists

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Figures: Frontiers in Nutrition 2025 (protein intake, n=69), STEP-1 (constipation, lean mass), 12-month discontinuation cohorts

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Why this matters: injectable GLP-1s like semaglutide and tirzepatide achieve 15 to 20% weight reductions, but injections, cost, and adherence limit real-world use (Santulli review, Journal of Diabetes & Metabolic Disorders, 2025)