The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)
o On Day 61 or thereafter, if: No additional glycemic control is needed maintain the dosage at 4 mg orally once daily
Women who become pregnant or are planning conception should discontinue tirzepatide and discuss alternative diabetes therapies with pregnancy safety data
For many people, this means weight loss and improved blood sugar control
While some research suggests that B12 levels may influence fat metabolism and body composition, the relationship isnt fully understood
There are several ways to increase B12 levels, but not all methods work the same for everyone