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Nielsen J, Friedman S, Norgard BM, Knudsen T, Kjeldsen J, Wod M
These materials facilitate osteogenic differentiation and mineralization of MSCs and have shown pro-osteogenic effects in periodontitis and calvarial defect models (Lee et al., 2018
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USA 102 , 1554515550 (2005)
In TJA, where the consequences of wound failure and PJI are severe, the absence of validated safety data is clinically meaningful
Such bidirectional interaction between hyperandrogenism and insulin resistance/hyperinsulinemia likely plays a key role in the pathogenesis of PCOS 12,13,14 , since elevated testosterone promotes obesity and insulin resistance/hyperinsulinemia by altering body composition and insulin signaling in skeletal muscle and adipose tissue, while hyperinsulinemia contributes to increase androgen levels via ovarian-dependent mechanisms 5
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