GLP-1 receptors are widely distributed throughout the body including the pancreas, gastrointestinal tract, and central nervous system, which helps explain both their broad therapeutic benefits and their diverse clinical effects
Draft Evidence Report
Sources Epidemiology and Clinical Outcomes of Vasomotor Symptoms Among Perimenopausal Women in the US: a Systematic Review Prevalence and Severity of Symptoms Across the Menopause Transition: Findings from the AMY Study Tirzepatide Prescribing Information - Drug Interactions: Oral Hormonal Contraceptives (FDA) Semaglutide Prescribing Information - Adverse Reactions (FDA, 2025) Wilding JPH et al
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FDAs briefing document is blunt
Weak or wrong reasons to switch: "Zepbound is newer so it must be better." Newer doesn't mean better for you individually