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This is especially true for patients with class II or class III obesity, patients with obesity-related medical problems, and patients who have lost and regained weight many times

This limitation reflects a broader gap in the field: most randomized controlled trials and systematic reviews focus on major depressive disorder or depressive symptoms in heterogeneous populations, without separate analyses for distinct presentations like vascular depression, treatment-associated depressive states, or mood disturbances in the context of specific medical conditions

55,57,148,155,157,161,163 About 25% of women between the ages of 15 and 44 use oral contraceptives, highlighting the importance of studying their potential DDIs

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Shefner, J