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Supplements are regulated but by a very different set of rules
TAS2R5 has been identified in L cells that secrete GLP-1, TAS2R38 is expressed in enteroendocrine cells (EECs) and has been related to CCK, PYY, and GLP-1 secretion (71, 72)
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Some patients also experience diminished gastrointestinal side effects (such as nausea) after several months of treatment, which may have initially contributed to reduced food intake
[21] However, it is important to note that these findings are preliminary, many are based on animal or in vitro studies, and there is no official link established between allulose consumption and clinically significant enhancement of GLP-1 activity in humans
Key Takeaways Tirzepatide (Zepbound) produces greater average weight loss than semaglutide (Wegovy) across both clinical trials and the first direct head-to-head comparison, 20.9% versus 14.9% in separate Phase 3 trials, and 20.2% versus 13.7% in the SURMOUNT-5 trial published in the New England Journal of Medicine
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