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Many many people are now taking it, very likely hundreds of thousands, perhaps even now into the millions
Validation within NHANES and Tianjin cohorts supported these causal associations
GLP-1 receptor agonists are transforming diabetes and obesity care
What few studies have been done in the pancreas (Koehler et al , 2009), while they did show some downregulation of specific cytokines (By itself, downregulation of specific cytokines is a rather unremarkable effect on the immune system, plenty of substances, that dont cure anything, can have similar effects), it did not show any actual improvements in outcomes in a rodent model of pancreatic inflammation
Notably, acetylcarnitine can act as an acetyl donor [37], supporting the acetylation process of cells through the shuttle mechanism of acetylcarnitine in the absence of conventional acetyl-CoA synthetase enzymes such as ATP-citrate lyase (ACLY) and acyl-CoA synthetase short chain 2 (ACSS2) [38]
Pemvidutide, an investigational GLP-1 and glucagon drug, stands out for preserving muscle unusually well (most of the Amycretin vs Zepbound: Investigational Newcomer vs Proven Option Amycretin and Zepbound represent two ends of the weight-loss drug timeline
