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It has also been used to treat premature ejaculation, chronic depression, pancreatitis, Parkinsons disease, and AIDS myelopathy

Preclinical timelines run over weeks meaningful model-level changes appear across roughly weeks 412, not in the first days

A diagnostic trial utilizing physiologic doses of vitamin B12 (1 mcg daily) and observing daily reticulocyte counts after establishing a baseline may also be performed

First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies