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These conserved residues are necessary but not sufficient for the ketosteroid isomerase activity
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Side effects are typically mild injection-site reactions, flushing, increased heart rate, nausea, headache
It is unclear why inhibition of c-MET by foretinib increased radiosensitivity, whereas inhibition with crizotinib appeared to have the opposite effect, though this phenomenon is likely due to other kinases targeted by these two molecules
While it may cause slightly more discomfort than the upper buttocks, it's generally easy to access and inject
