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Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45
Frontiers in Bioengineering and Biotechnology [Internet]
Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS
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Animal models demonstrate robust neuroprotection in optic nerve crush and ischemia models
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