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Ibuprofen is insoluble in water, thus organic solvents such as ethanol, DMSO or dimethyl-formamide are needed for its pharmaceutic formulations that makes its safe applicability a challenge [70]
In turn, this can result in a greater chance of cancer recurrence and lower survival rates
MOTS-c acts independently of the GH axis Metabolic mechanism / AOD-9604 targets lipolysis
DOPAL conjugates with lysine residues of -syn forming SB and MA adducts, leading to the formation of -syn oligomers, aggravating -syn toxicity, and this can be abrogated by a lysine-blocking strategy [68]