A 2004 study by Korkushko et al
Oral might help gut issues but evidence is limited
28-30 However, an unblinded randomized controlled trial (RCT) comparing the efficacy of metformin (500 mg 3 times daily) with rosiglitazone (4 mg/d), another T2DM medication, on AN neck lesions in patients who were overweight and obese found no significant effects in lesion severity and only modest improvements in skin texture in both groups at 12 weeks following treatment initiation
Not quite sure why, might want to look into that one
Creams offer surface-level benefits, while supplements work from within
George region including Mesquite, NV GLP-1 and GIP medications support healthier metabolism, stronger cardiovascular function, and overall longevity