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Afamelanotide was carried down the full pharmaceutical pathway: a defined molecule, a slow-release implant formulation, controlled clinical trials, and eventually orphan-drug approval for a rare disease

Large injection volumes also raise the question of depot mechanics: if the formulation is, say, a microsphere suspension, injecting a lot of material could cause nodules or induration in the tissue

Always use sunscreen during the day when using any retinol product