A 2022 systematic review and network meta-analysis published in The Lancet found that phentermine-topiramate treatment resulted in an average of nearly 8% weight losssuperior to most other medications studied or to lifestyle modifications alone
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Balette pushes back on the old ladder model: diet and exercise first, then medication, then surgery only if everything else fails
Contact your GP or bariatric team promptly if you experience: Repeated fainting or loss of consciousness Blood pressure readings consistently below 90/60 mmHg Severe dizziness that prevents normal daily activities Signs of significant dehydration, such as very dark urine, dry mouth, or no urination for more than eight hours Chest pain, shortness of breath, or palpitations alongside low blood pressure Severe abdominal pain, black or tarry stools, fever, or rigors alongside low blood pressure, as these may indicate early post-operative complications requiring urgent assessment Symptoms that are worsening rather than improving over time If you are unsure and it is not an emergency, contact NHS 111 for urgent advice
Neurochemistry Int (2016) 99:11032