Palmitoylation is a reversible form of lipidation in which a saturated fatty acid, palmitic acid, is enzymatically attached to a free cysteine residue near the protein-lipid interface, forming a thioester linkage with the cysteine residue[37]
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Its primary role is to protect cells from oxidative stressa process where unstable molecules called free radicals cause damage to cellular structures
10.1002/cncr.27459 Cancer 80 RoyS.LeviE.MajumdarA
Under oxidative conditions, Nrf2 escapes Keap1-mediated ubiquitination and translocates into the nucleus, where it induces the expression of antioxidant genes involved in glutathione (GSH) synthesis, NADPH production, and cellular detoxification [34]