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Close monitoring is essential, particularly for individuals who are sensitive to stimulants effects (eg, insomnia, appetite suppression, and increased heart rate, with growth suppression being a potential long-term concern in children)

It is particularly important not to discontinue semaglutide without medical guidance, as abrupt cessation may lead to deterioration in glycemic control or weight regain

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drug interactions [1] Phenobarbital is an inducer of CYP 2B6, 3A4, 2C9, and 2C19, which may lead to inadequate levels of medications metabolized by these pathways

Key Takeaways: Low Energy on Tirzepatide and What to Do About It Tiredness is a reported side effect of tirzepatide, especially early on