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Quite recently, a population-based case-control study, which included 1.011 MDS that reported their use of supplements containing folic acid at peri-conception, showed that lack of maternal folic acid supplementation was more frequent among infants with DS and AVSD (OR = 1.69

The 3040% rebound hyperpigmentation rate at discontinuation means hydroquinone is a management tool, not a permanent solution

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Defective autophagy heightens TECs susceptibility to ferroptosis in DKD, demonstrating the close correlation between autophagy flux impairment and ferroptosis (79)