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Bergmann et al

Over 80% of participants in both groups reported GI-related issues such as constipation, cramping, bloating, and diarrhoea

After 3 months of treatment with Tioneural retard, patients reported a statistically significant reduction in neuralgic pain measured with the VAS scale (-62.3%)

This typically becomes noticeable 2 to 3 weeks after the final dose, when circulating retatrutide levels have dropped below the therapeutic threshold