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This anti-autophagic effect of GLP-1 on endothelial cells at an early stage may be crucial for preventing arteriosclerosis which will further lead to serious cardiovascular complications

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The peptide induced expression of cytoskeleton proteins, intracellular kinases, and transcription regulators while repressing immune and inflammatory mediators, leading to down-regulation of oxidative stress response and up-regulation of ion channels and metabolic pathways

AR-NKGCD is a rare disorder with a variable phenotype