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Studies have consistently shown elevated levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and other inflammatory cytokines directly inhibit Leydig cell function and reduce LH sensitivity

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So, when you lose all this fat-free mass where youve got a lot of muscle in there, is that going to, in the long term, cause serious issues

Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, et al

SCID-I, the Structured Clinical Interview for Axis I DSM-IV Disorders-Patient Version