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10.1371/journal.pone.0064759 75 LuoY.OuyangJ.ZhouD.ZhongS.WenM.OuW.et al

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Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function

Sometimes, with physician guidance