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According to WHO report, there are respectively around 815 and 176 million children with blood lead level higher than 5 g/dl and 10 g/dl (Rees and Richard 2020)

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As the K4 and SPH domains belong to the and subunits of HGF, respectively, such strong K4/SPH interaction would be important for the structural integrity of HGF / heterodimer in addition to the disulfide bond between these two subunits