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Retatrutide's glucagon component is new territory for the agency
Weeks 9-12 (if needed): 1 mg once weekly
This obviously results in improved glucose control and reduced calorie intake, consistently demonstrated in several clinical trials, including: STEP 1 trial, where adults with obesity who were treated with semaglutide lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group (Wilding et al., 2021, New England Journal of Medicine)
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GLP-1 drugs can cost over $1,000 per month for treatment, and once started, must be continued for life
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