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The situation is not entirely conclusive since knock-out of the CCK-1 receptor in mice does not result in a similar phenotype

doi: 10.1182/bloodadvances.2022007458 Oldenburg J, Mahlangu JN, Kim B, et al

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Gallbladder motor function, plasma cholecystokinin and cholecystokinin receptor of gallbladder in cholesterol stone patients

However, many patients still achieve meaningful results (1015% body weight loss) with oral form if they take it consistently and on an empty stomach

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