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Lee SH, Min SH, Cho YC, Han JH, Kim MN, Kim CR, et al
2025;135(21):e194751) documents that GLP-1 receptor agonist signaling reduces systemic and tissue inflammation through both weight lossdependent and weight lossindependent mechanisms
More striking: DEXA scans showed lean mass preservation in 89% of dual-therapy patients versus 71% in monotherapy patients
Reduced Inflammation : Some users have reported anti-inflammatory benefits, which can be particularly useful for conditions like lipedema, where inflammation plays a significant role
Eli Lilly plans to submit orforglipron GLP-1 pill data to the FDA by the end of the year for consideration of the pill for weight loss management, and for Type 2 diabetes management in early 2026
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