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There are simply too many signals at work in our bodies to ensure full calorie storage At the same time, we observed that key hormones regulating body weight, like the satiety hormone leptin and the hunger hormone ghrelin, were acting in the brain to achieve their effects

Herv F, Ghinea N, Scherrmann JM

The drug seemed to be a better option

Because they have personally experienced a reduced desire for food, they are more likely to anticipate a decline in overall demand, translating into lower revenues and profitability expectations for restaurants, grocery stores, and food manufacturers

A 2022 review in the Journal of Clinical Endocrinology and Metabolism confirmed this effect is dose-dependent with semaglutide

Diabetes 46 (5), 824828