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Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial
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GSSG is converted to reduced glutathione form with GR enzyme by a reaction in which NADPH is used [21, 30, 33]
As it inhibits melanin production, glutathione may also improve the appearance of freckles
While metformin has long served as the standard first-line therapy, many clinicians are now reconsidering whether a metformin-first and wait strategy is enough for this higher-risk population
