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Both tirzepatide and semaglutide come with boxed warnings from the FDA (the strongest safety warning for prescription drugs) about the risk of developing thyroid C-cell tumors

DOI:10.1016/0959-8049(95)00310-F [ Links ] 30

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Hepatoma cell lines, such as HepG2, in general display lower expression levels of hepatic phase I and phase II enzymes compared with primary hepatocytes, thus questioning their informative value for the situation in vivo