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Legal Status United States: Not FDA-approved for human use
10.1371/journal.pone.0027706 PLoS One 96 KitamuraK.IwanamiA.NakamuraM.YamaneJ.WatanabeK.SuzukiY.et al (2007)
What is already known on this topic Concerns exist about a potential association between glucagon-like peptide-1 receptor (GLP-1) agonists and suicidality This has prompted regulatory agencies to conduct comprehensive reviews of this drug class Observational studies investigating this safety concern remain inconclusive
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In vivo characterization of functional states of cortical microglia during peripheral inflammation
Novo Nordisk's Rybelsus showed that transcellular gastric absorption, boosted with SNAC, can partially get around the first two problems, but cannot solve the third
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