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Ensuring absolute targeting specificity to the TME to preserve peripheral immunity remains a critical biodistribution challenge for these platforms ( 3.3 Modulating CAFs and ECM CAFs contribute to immunotherapy resistance through multiple mechanisms, including physical barrier formation, secretion of immunosuppressive cytokines, and metabolic reprogramming of the TME (34)

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This suggests that estrogen may help stimulate the production of antioxidants to protect tissues from the natural fluctuations of the cycle

Additionally, low glutathione levels can increase the risk of developing chronic diseases

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