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VMAT2 exhibits higher affinity for monoamine substrates than does VMAT1, and VMAT2 is expressed in all monoaminergic neurons in the brain

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NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier

Engaging in regular physical activity can also promote better hormonal balance and improve mood, making it an essential component of a holistic approach to thyroid health

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Starting with a lower dose (such as 500mg once or twice daily) and gradually increasing may improve tolerability