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doi: 10.1016/j.cell.2025.06.032 54
The review confirmed GLP-1R is expressed at high levels on -cells, where GLP-1 stimulates somatostatin secretion which in turn indirectly suppresses both glucagon and insulin through paracrine mechanisms
Where does metformin stand in modern day management of type 2 diabetes
GLP-1R as a Target for Diabetes and Other Diseases Type 2 diabetes also known as adult-onset diabetes is the most common form of diabetes in human populations, estimated to affect over 450 million individuals, corresponding to over 6% of the worlds population
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