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Maintain the supporting factors that affect outcomes

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This study innovatively focuses on the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells, demonstrating that it functions by activating the p53/BCL-2/Caspase-3 signaling pathway to promote selective apoptosis of these cells

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Common themes include rapid onset of anti-inflammatory effects (often within days), gradual improvement in function over weeks, and best results when combined with appropriate physical therapy and lifestyle modifications