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45 All studies that demonstrated a reduction in MACE on GLP-1RA therapy consistently involved patients with T2D
Interaction between the non-catalytic cysteine at position 129 and the catalytic cysteine 227 shows the formation of a disulfide bond, which maintains its catalytic activity (91, 92)
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Additionally, these genetic variations were separate from those influencing GLP1R gene expression levels
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