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Specific concerns include post-cholecystectomy syndrome (a cluster of persistent GI symptoms in 1015% of patients) and potential interactions between GLP-1-induced motility changes and pre-existing bile acid malabsorption

Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P

For mitochondrial functionality, the model included group (CON or CAR), time (relative to LPS injection), stimulus (unstimulated, ConA or LPS) and their interactions as fixed factors

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