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Since ascorbate is a hydrophilic chemical, it reacts at the lipid/water interface to shield cell membranes from oxidative stress and free radicals in the cytosol [167,168,169,170]

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Accompanied by impaired BBB integrity, these peripheral immune factors gain access to the CNS, where they mediate neuroinflammatory responses, resulting in synaptic damage and neuronal dysfunction

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The clinical benchmark is one to two pounds per week

A plethora of PASC clinical symptoms and related metabolic impairments indicate an involvement of various pathophysiological mechanisms originating from virus-induced HMRD