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Future large long-term RCTs with primary or secondary outcomes, including thyroid disorders and real-world data, are needed to elucidate the association between GLP-1 receptor agonists and the risk of various thyroid disorders, particularly thyroid cancer

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Bile acid sequestrants have also been demonstrated to control glucose and lipid levels by activating the signaling pathways TGR5 and FXR, which are involved in glucose and lipid homeostasis (50)

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