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The treatment increased the abundance of beneficial genera such as Lachnospiraceae , Ruminococcus , and Akkermansia

The lactulose/mannitol test involves oral use of these sugars followed by measurement of their urinary excretion increased lactulose/mannitol ratio shows increased gut permeability

Mechanistically, TRIM37 binds TRIM28 through its MATH domain and ubiquitinates TRIM28 via its RING domain, enhancing the TRIM37TRIM28 interaction and promoting the nuclear retention of TRIM37

Oct-Dec 2004;25(5-6):455-73