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Use oral rehydration solutions, stick to bland, small meals until stools normalize, and avoid taking anti-diarrheal agents as a long-term fix without medical advice

Specifically, GLP-1 receptors are enriched in the lateral septum (where expression is highest), hypothalamus, amygdala, bed nucleus of the stria terminalis, hippocampus, ventral tegmental area (VTA), and nucleus accumbens (NAc)

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Novo Nordisk published two studies in 2018 on the pharmacokinetics, safety, and tolerability of smeglutide in subjects with liver injury or renal insufficiency