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Elevated levels of sphingosine 1-phosphate receptor 1, which contributes to blood-brain barrier permeability in epileptic brains through the promotion of neuroinflammation, were detected alongside reduced levels of tight junction proteins in mice induced with pilocarpine-induced status epilepticus (168)

Allegations suggest the company used software to propose additional diagnoses and offered financial incentives to physicians for documenting conditions that may not have been present, potentially leading to an $8.7 billion increase in federal payments in 2021 alone

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