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Increased BMR & Mitochondrial Output: Enhances calorie burn and endurance potential (Kraus et al., Nature Medicine )

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In most cases, methylcobalamin is nontoxic, even in large doses

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Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities