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Conclusion: Glutathione is safe, tolerable and effective whitening agent when used in topical cream (2%) and also in oral form in treatment of melasma.
H.LangfordN.KendallM
Educational reference content
The two cysteines in this motif catalyze glutathione (GSH)-dependent thiol-disulfide exchange reactions, i.e., the reduction of protein disulfides and, with high specificity, reversible (de-)glutathionylation [19] Oxidized Grxs are reduced by GSH, the resulting GSH disulfide (GSSG) by glutathione reductase (GR) using NADPH as electron source [20]
these should be stockpiled in the regional and/or district distribution hubs Urgent antidotes, to be administered within 624 h Other antidotes (succimer) can be stockpiled nationally or in the most prevalent regions depending on demand
Understanding the mechanism helps explain why its effects are so broad
